| Changes of Subtypes of Anterior Vaginal Wall Collagen in Female with Stress Urinary Incontinence. |
|
| Byung Ik Jeong, Young Jun Seo, Bu Kyung Park, Jeong Ju Lee |
1Department of Urology, College of Medicine, Pusan National University, Busan, Korea. zjlee@pusan.ac.kr
2Jeong's Urology Clinic, Korea. |
|
|
|
|
| ABSTRACT |
PURPOSE
Objective of this study is to determine changes in the levels of type I and III collagen in women with stress urinary incontinence (SUI).
MATERIALS AND METHODS
Forty-nine women were enrolled to this study and e divided into two groups. Forty-four patients with SUI and 5 patients with without SUI for control. All the women were underwent a pre-operative evaluation. The presence of collagen type I and III was determined by immunohistochemical technique. Analysis of staining was studied with help of specialist of pathology with Image Pro computerized program. The student t-test was used for statistical analysis.
RESULTS
Collagen type I and III was significantly reduced (p<0.05) in patients with SUI in anterior vaginal wall tissue. compared to patients in control. Both collagen type I and III were marked reduced in the patient of severe grade of stress urinary incontinence.
However there were no significant relation between quantity of collagen and other etiological factors including age, parity, grade, and menopausal.
CONCLUSION
In this study, women with SUI have less collagen type I and III around the urethra regardless of the degree of pelvic relaxation, SUI grade, parity, menopausal, age. It appears that collagen has a significant role in the maintenance of urinary continence. |
| Keywords:
Collagen types; Vaginal wall; Stress urinary incontinence |
|
PDF Links
Full text via DOI
Download Citation
