| Efficacy and Safety of Propiverine Hydrochloride 40mg in Treatment of Overactive Bladder : Prospective, Multicenter, Observational study. |
|
| Su Jin Kim, Won Yeal Cho, Jung Sik Huh, Ju Tae Seo, Sang Kuk Yang, Kyu Sung Lee, Ju Hwan Lee, Myung Soo Choo, Ha Young Kim, Chul Hee Park, Joon Chul Kim |
1Department of Urology, The catholic University of Korea College of Medicine, Korea. kjc@catholic.ac.kr
2Department of Urology, Dong-A University College of Medicine, Korea.
3Department of Urology, Cheju University School of Medicine, Korea.
4Department of Urology, Kwandong University College of Medicine, Korea.
5Department of Urology, Konkuk University College of Medicine, Korea.
6Department of Urology, Sungkyunkwan University School of Medicine, Korea.
7Department of Urology, Daegu Fatima Hospital, Korea.
8Department of Urology, University of Ulsan College of Medicine, Korea.
9Department of Urology, School of Medicine Hallym University, Korea.
10Department of Urology, Keimyung University School of Medicine, Korea. |
|
|
|
|
| ABSTRACT |
PURPOSE
This study aims to compare the efficacy and safety of propiverine hydrochloride (propiverine) 40mg for the treatment of overactive bladder (OAB).
MATERIAL AND METHODS: Total of 284 patients (male:86, female:198) with OAB were included in this study. The patients were treated with propiverine 20mg twice daily or 40mg once daily for 8 weeks. The initial evaluation included with history taking, physical examination, International Prostatic Symptom Score (IPSS), IPSS QoL and consecutive voiding diaries for 3 days. After a 8-week treatment, IPSS, IPSS QoL, patients perception of treatment benefit, global assessment of efficacy by physicain and safety were evaluated.
RESULTS
Two hundred eighteen patients were treated with propiverine 20mg twice daily and 66 patients treated with 40mg once daily. The 59 patients had been treated previously with anticholinergics. After a 8-week treatment, IPSS score (total, voiding and storage subscore) and IPSS QoL were improved in all patients (p<0.05). After a 8-week with propiverine 40mg once daily, improvement of IPSS score was noted in the patients non-responsive to anticholinergics previously (p<0.05). The patients treated with propiverine 40mg once daily showed much more symptomatic improvements assessed by physicians than 20mg twice daily (p<0.05). The overall side effect was noted in the 13.4% patients and the most common side effect was dry mouth.
CONCLUSION
Propiverine 40mg once daily is considered to reduce the symptom of OAB effectively and can be used safely in the patients with OAB. Treatment with propiverine 40mg is seemed to show more improvement in the unsatisfactory patients with previous anticholinergics. |
| Keywords:
Overactive bladder; Propiverine hydrochloride; Treatment outcome |
|
PDF Links
Full text via DOI
Download Citation
