Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease

  

Videourodynamics — role, benefits and optimal practice

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Nature Reviews Urology.2025; 22(3): 130.     CrossRef

Anti-inflammatory effect of sea buckthorn in an HCl-induced cystitis rat model

Hyun Suk Yoon, Juyeon Yu, Shinhoon Kang, Hana Yoon

Investigative and Clinical Urology.2025; 66(1): 67.     CrossRef

The exposure to volatile organic compounds associate positively with overactive bladder risk in U.S. adults: a cross-sectional study of 2007–2020 NHANES

Dawen Zhang, Ziyi Yan, Junhao He, Yunmin Yao, Kai Liu

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Wnt/β-catenin signaling inhibits oxidative stress-induced ferroptosis to improve interstitial cystitis/bladder pain syndrome by reducing NF-κB

Weilin Fang, Xin Song, Hailong Li, Fanguo Meng, Tingting Lv, Jin Huang, Xiang Ji, Jianwei Lv, Zhikang Cai, Zhong Wang

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2024; 1871(7): 119766.     CrossRef

Divergent histopathological and molecular patterns in chemically induced interstitial cystitis/bladder pain syndrome rat models

Ya-Chuan Chang, Chia-Ying Yu, Chen Dong, Sung-Lang Chen, Wen-Wei Sung

Scientific Reports.2024;[Epub]     CrossRef

Emodin suppresses mast cell migration via modulating the JAK2/STAT3/JMJD3/CXCR3 signaling to prevent cystitis

Ke Xin, Manqing Ge, Xukun Li, Hongwei Su, Jingwei Ke, Kaifa Chen, Yiquan Tang, Yinghong Wang, Junyu Lai

Neurourology and Urodynamics.2024; 43(8): 2258.     CrossRef

Cellular and Molecular Aspect of Bladder Pain Syndrome: An Entry Point to Exploration of Its Pathogenesis

Kuni Sumargo, Abdi Hasanuddin

International Journal of Clinical Urology.2024; 8(2): 12.     CrossRef

The Pathomechanism and Current Treatments for Chronic Interstitial Cystitis and Bladder Pain Syndrome

Wan-Ru Yu, Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo

Biomedicines.2024; 12(9): 2051.     CrossRef

Serpina3n/serpina3 alleviates cyclophosphamide-induced interstitial cystitis by activating the Wnt/β-catenin signal

Weilin Fang, Qixiang Song, Tingting Lv, Jianwei Lv, Zhikang Cai, Zhong Wang, Xin Song, Xiang Ji, Jin Huang

International Urology and Nephrology.2023; 55(12): 3065.     CrossRef

Sensory Receptor, Inflammatory, and Apoptotic Protein Expression in the Bladder Urothelium of Patients with Different Subtypes of Interstitial Cystitis/Bladder Pain Syndrome

Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. Birder, Hann-Chorng Kuo

International Journal of Molecular Sciences.2023; 24(1): 820.     CrossRef

Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment

Alessandro Tafuri, Andrea Panunzio, Rita De Mitri, Federico Benetti, Elisa Gaio, Vincenzo Pagliarulo

Cells.2023; 12(4): 616.     CrossRef

Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway

Zong-Sheng Wu, Hou-Lun Luo, Yao-Chi Chuang, Wei-Chia Lee, Hung-Jen Wang, Michael B. Chancellor

Biomedicines.2023; 11(3): 935.     CrossRef

Animal models of interstitial cystitis/bladder pain syndrome

Cindy Tay, Luke Grundy

Frontiers in Physiology.2023;[Epub]     CrossRef

Intravesical injections of autologousplatelet‐richplasma for the treatment of refractory interstitial cystitis

Hann‐Chorng Kuo

LUTS: Lower Urinary Tract Symptoms.2023; 15(6): 210.     CrossRef

Bladder Pain Syndrome Associated with Interstitial Cystitis: Recent Research and Treatment Options

Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo

Current Bladder Dysfunction Reports.2023; 18(4): 389.     CrossRef

Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats

Hung-Jen Wang, Pradeep Tyagi, Tsu-Kung Lin, Chao-Cheng Huang, Wei-Chia Lee, Michael B. Chancellor, Yao-Chi Chuang

Biomedical Journal.2022; 45(3): 482.     CrossRef

Low-Energy Shock Wave Plus Intravesical Instillation of Botulinum Toxin A for Interstitial Cystitis/Bladder Pain Syndrome: Pathophysiology and Preliminary Result of a Novel Minimally Invasive Treatment

Yuan-Hong Jiang, Jia-Fong Jhang, Yu-Khun Lee, Hann-Chorng Kuo

Biomedicines.2022; 10(2): 396.     CrossRef

Electro-Acupuncture for Bladder Pain Syndrome: A Protocol of a Randomized Controlled Trial and Study for Central Mechanism

Yunyun Xu, Yangyun Chen, Yan Shi, Jianhua Lu, Zonglin Wu, Zhe Liu, Yuerong Chen, Wenqin Ni, Qike Ding, Wei Dai, Xinyuan Wu, Jianqiao Fang, Yuanyuan Wu

Journal of Pain Research.2022; Volume 15: 1959.     CrossRef

Urine Oxidative Stress Biomarkers as Novel Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome

Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo

Biomedicines.2022; 10(7): 1701.     CrossRef

Current Understanding of the Pathophysiology and Novel Treatments of Interstitial Cystitis/Bladder Pain Syndrome

Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo

Biomedicines.2022; 10(10): 2380.     CrossRef

Usefulness of Urinary Biomarkers for Assessing Bladder Condition and Histopathology in Patients with Interstitial Cystitis/Bladder Pain Syndrome

Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo

International Journal of Molecular Sciences.2022; 23(19): 12044.     CrossRef

Bladder pain syndrome in men

Laura Derbyshire, Ian Pearce

Trends in Urology & Men's Health.2022; 13(6): 20.     CrossRef

Stress-Induced Changes in Trophic Factor Expression in the Rodent Urinary Bladder: Possible Links With Angiogenesis

Mathijs M. de Rijk, Amanda Wolf-Johnston, Aura F. Kullmann, Katherine Maringer, Sunder Sims-Lucas, Gommert A. van Koeveringe, Larissa V. Rodríguez, Lori A. Birder

International Neurourology Journal.2022; 26(4): 299.     CrossRef

Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome

Liao Peng, Xing-peng Di, Shi-xin He, Xiao Zeng, Hong Shen, Hui-li Zhu, De-yi Luo

International Urogynecology Journal.2021; 32(5): 1299.     CrossRef

Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

Yang Yang, Hengshuai Zhang, Qudong Lu, Xin Liu, Yi Fan, Jingzhen Zhu, Bishao Sun, Jiang Zhao, Xingyou Dong, Longkun Li

Biochemical Pharmacology.2021; 183: 114340.     CrossRef

Feline Idiopathic Cystitis: Pathogenesis, Histopathology and Comparative Potential

Emily Jones, Chiara Palmieri, Mary Thompson, Karen Jackson, Rachel Allavena

Journal of Comparative Pathology.2021; 185: 18.     CrossRef

Comparative safety review of current pharmacological treatments for interstitial cystitis/ bladder pain syndrome

Po-Yen Chen, Wei-Chia Lee, Yao-Chi Chuang

Expert Opinion on Drug Safety.2021; 20(9): 1049.     CrossRef

Voiding dysfunctions in patients with non‐Hunner's ulcer interstitial cystitis/bladder pain syndrome do not affect long‐term treatment outcome

Wan‐Ru Yu, Wei‐Chuan Chang, Hann‐Chorng Kuo

International Journal of Clinical Practice.2021;[Epub]     CrossRef

Peripheral antinociceptive effects of a bifunctional μ and δ opioid receptor ligand in rat model of inflammatory bladder pain

Maia Terashvili, Bhavana Talluri, Watchareepohn Palangmonthip, Kenneth A. Iczkowski, Patrick Sanvanson, Bidyut K. Medda, Banani Banerjee, Christopher W. Cunningham, Jyoti N. Sengupta

Neuropharmacology.2021; 196: 108701.     CrossRef

Anesthetic Bladder Capacity is a Clinical Biomarker for Interstitial Cystitis/Bladder Pain Syndrome Subtypes

Andre Plair, Robert J. Evans, Carl D Langefeld, Catherine A Matthews, Gopal Badlani, Stephen J. Walker

Urology.2021; 158: 74.     CrossRef

Difference in electron microscopic findings among interstitial cystitis/bladder pain syndrome with distinct clinical and cystoscopic characteristics

Yu Khun Lee, Jia-Fong Jhang, Yuan-Hong Jiang, Yung-Hsiang Hsu, Han-Chen Ho, Hann-Chorng Kuo

Scientific Reports.2021;[Epub]     CrossRef

A step toward precision diagnosis of interstitial cystitis

Hann-Chorng Kuo

Urological Science.2021; 32(1): 8.     CrossRef

Urinary Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome and Its Impact on Therapeutic Outcome

Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan

Diagnostics.2021; 12(1): 75.     CrossRef

The Level of Epidermal Growth Factor and Its Relationship with Leukocytes and Mast Cells in Experimental Interstitial Cystitis / Painful Bladder Syndrome

R. F. Sholan

Urology Herald.2020; 7(4): 20.     CrossRef

Cognition, Emotion, and the Bladder: Psychosocial Factors in Bladder Pain Syndrome and Interstitial Cystitis (BPS/IC)

Sula Windgassen, Lindsey McKernan

Current Bladder Dysfunction Reports.2020; 15(1): 9.     CrossRef

Effect of Botulinum Toxin A on Bladder Pain—Molecular Evidence and Animal Studies

Ting-Chun Yeh, Po-Cheng Chen, Yann-Rong Su, Hann-Chorng Kuo

Toxins.2020; 12(2): 98.     CrossRef

The surgical options for Hunner’s lesions: an update

Anthony Simon Bates, Jaskarn S Rai, Jonathan Charles Goddard

Journal of Clinical Urology.2020; 13(3): 242.     CrossRef

Application of Adult and Pluripotent Stem Cells in Interstitial Cystitis/Bladder Pain Syndrome Therapy: Methods and Perspectives

Ahmed Abdal Dayem, Kyeongseok Kim, Soo Bin Lee, Aram Kim, Ssang-Goo Cho

Journal of Clinical Medicine.2020; 9(3): 766.     CrossRef

Changes in uroplakin expression in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome

Kang Jun Cho, Kyu-Sung Lee, Jin Bong Choi, Jun Sung Koh, Joon Chul Kim

Investigative and Clinical Urology.2020; 61(3): 304.     CrossRef

Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion

Subbroto Kumar Saha, Tak-Il Jeon, Soo Bin Jang, Se Jong Kim, Kyung Min Lim, Yu Jin Choi, Hyeong Gon Kim, Aram Kim, Ssang-Goo Cho

Journal of Clinical Medicine.2020; 9(6): 1935.     CrossRef

New Frontiers or the Treatment of Interstitial Cystitis/Bladder Pain Syndrome - Focused on Stem Cells, Platelet-Rich Plasma, and Low-Energy Shock Wave

Chih-Chieh Lin, Yun-Ching Huang, Wei-Chia Lee, Yao-Chi Chuang

International Neurourology Journal.2020; 24(3): 211.     CrossRef

Stratification of Patients With Interstitial Cystitis/Bladder Pain Syndrome According to the Anatomical Bladder Capacity

Charles Mazeaud, Jérôme Rigaud, Amélie Levesque, François-Xavier Madec, Quentin-Come Le Clerc, Maxime Wack, Loïc Le Normand, Thibault Riant, Marie-Aimée Perrouin- Verbe

Urology.2019; 123: 87.     CrossRef

The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception

Tsuyoshi Majima, Kenichi Mori, Katsumi Kadekawa, Shun Takai, Yasuhito Funahashi, Bonnie Reinhart, William F. Goins, Momokazu Gotoh, Joseph C. Glorioso, Naoki Yoshimura

Neurourology and Urodynamics.2019; 38(2): 582.     CrossRef

Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

Maryam Karamali, Rana Shafabakhsh, Zinat Ghanbari, Tahereh Eftekhar, Zatollah Asemi

Journal of Cellular Physiology.2019; 234(8): 12301.     CrossRef

Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis

Karol Borys Tudrej, Tomasz Piecha, Małgorzata Kozłowska-Wojciechowska

Therapeutic Advances in Urology.2019;[Epub]     CrossRef

Bladder Pain Syndrome

Miranda M. Huffman, Aniesa Slack, Maris Hoke

Primary Care: Clinics in Office Practice.2019; 46(2): 213.     CrossRef

Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population‐based cohort study

Jen‐Yu Wen, Tsia‐Shu Lo, Yao‐Chi Chuang, Chung‐Han Ho, Cheng‐Yu Long, Kim‐Seng Law, Yat‐Ching Tong, Ming‐Ping Wu

International Journal of Urology.2019; 26(9): 897.     CrossRef

Transvaginal Trigger Point Injections Improve Pain Scores in Women with Pelvic Floor Hypertonicity and Pelvic Pain Conditions

Jamie Bartley, Esther Han, Priyanka Gupta, Natalie Gaines, Kim A. Killinger, Judith A. Boura, Morgan Farrah, Jason Gilleran, Larry T. Sirls, Kenneth M. Peters

Female Pelvic Medicine & Reconstructive Surgery.2019; 25(5): 392.     CrossRef

Preclinical Animal Studies of Intravesical Recombinant Human Proteoglycan 4 as a Novel Potential Therapy for Diseases Resulting From Increased Bladder Permeability

Beverley Greenwood-Van Meerveld, Ehsan Mohammadi, Rocco Latorre, Edward R. Truitt, Gregory D. Jay, Benjamin D. Sullivan, Tannin A. Schmidt, Nataliya Smith, Debra Saunders, Jadith Ziegler, Megan Lerner, Robert Hurst, Rheal A. Towner

Urology.2018; 116: 230.e1.     CrossRef

IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model

M. Martin Jensen, Wanjian Jia, Austin J. Schults, Xiangyang Ye, Glenn D. Prestwich, Siam Oottamasathien

Cytokine.2018; 110: 420.     CrossRef

Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition

Jia-Fong Jhang, Han-Chen Ho, Yuan-Hong Jiang, Cheng-Ling Lee, Yuan-Hsiang Hsu, Hann-Chorng Kuo, Robert Hurst

PLOS ONE.2018; 13(6): e0198816.     CrossRef

Current Therapeutic Strategies in Clinical Urology

Alice Crane, Sudhir Isharwal, Hui Zhu

Molecular Pharmaceutics.2018; 15(8): 3010.     CrossRef

Is It Possible to Prevent Symptom Recurrence After Transurethral Resection for Hunner Lesion?

Aram Kim, Jung Hyun Shin, Myung-Soo Choo

International Neurourology Journal.2018; 22(2): 145.     CrossRef

Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain Syndrome/Interstitial Cystitis: A Nationwide Population-Based Study

Ming Ping Wu, Hao Lun Luo, Shih Feng Weng, Chung-Han Ho, Michael B. Chancellor, Yao Chi Chuang

BioMed Research International.2018; 2018: 1.     CrossRef

Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome

Luke Grundy, Ashlee Caldwell, Stuart M. Brierley

Frontiers in Neuroscience.2018;[Epub]     CrossRef

An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome

Li Zhang, Awais Ullah Ihsan, Yanfang Cao, Farhan Ullah Khan, Yijie Cheng, Lei Han, Xiaohui Zhou

Inflammation.2017; 40(6): 2033.     CrossRef

Chronic Pelvic Pain and Neuropelveology

Young Sam Cho

International Neurourology Journal.2017; 21(4): 233.     CrossRef

Are We Ready to Use the Omics Strategies for Precision Medicine?

Jayoung Kim

International Neurourology Journal.2016; 20(Suppl 2): S65.     CrossRef