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Int Neurourol J > Volume 10(1); 2006 > Article
Fundamental Science for Neurourology
Journal of the Korean Continence Society 2006;10(1): 38-43.
DOI: https://doi.org/10.5213/jkcs.2006.10.1.38   
Effect of ABT-594 a Selective Nicotinic Agonist, on Voiding Function in Spinal Cord Injury Rat.
Hyun Rho, Sun Ju Lee, Sung Goo Chang
1Department of MRC, Kyung Hee University School of Medicine, Seoul, Korea. sjlee@khu.ac.kr
2Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
ABSTRACT
PURPOSE
In this study we demonstrate effect of selective nicotinic agonist, ABT-594 on voiding in spinal cord injury rat.
MATERIALS AND METHODS
Spinal cord injury rat was made by complete resection of the spinal cord(T8~9) and checked cystometry three weeks after injury. In female Sprague-Dawley awake rats, an intravesical catheter was inserted through the bladder dome and intravenous catheter was inserted to right jugular vein. After the surgery, cystometry was performed by infusing saline into the bladder(0.08 ml/min). Cumulative doses of ABT-594 (0.01, 0.1, 1, 10 ug/kg) were injected intravenously in spinal cord injury rat at 1 hour intervals.
RESULTS
All dose(0.01~10 ug/kg) of ABT-594 did not affect the intercontraction interval(ICI), maximal voiding pressure(MVP), and pressure threshold(PT), and from voiding contraction to non-voiding contraction(from VC to NVC), voiding volume(VV), residual volume(RV). But moderate dose(1 ug) of ABT-594 significantly decreased number of non-voiding contraction(55.6+/-13.7% of control)(p<0.05).
CONCLUSION
These result suggest that the nicotinic agonist ABT-594 might in part affect voiding function through stimulation of serotonergic nerve to lumbosacral level in spinal cord injury rat.
Keywords: Spinal cord injury; Nicotinic agonist; ABT-594; Bladder


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