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Int Neurourol J > Volume 13(2); 2009 > Article
Journal of the Korean Continence Society 2009;13(2): 83-89.
DOI: https://doi.org/10.5213/jkcs.2009.13.2.83   
Role of Nerve Growth Factor in Overactive Bladder.
Joon Chul Kim
Department of Urology, The Catholic University of Korea, College of Medicine, Seoul, Korea. kjc@catholic.ac.kr
ABSTRACT
Overactive bladder (OAB) is defined by the International Continence Society (ICS) as urgency, with or without urge incontinence, usually with frequency and nocturia. There have been many studies about OAB, but the cause and mechanisms are still poorly understood. It has been postulated that nerve growth factor (NGF) provide mechanisms for bidirectional communication between muscle or urothelium and nerve, leading to OAB. NGF is a secretory protein that has a critical role in the development of the peripheral nervous system. The bladder, especially the urothelium can produce NGF, which play a role in afferent sensitization. Elevated NGF levels orchestrate changes in sodium channel expression that, in turn, lower afferent nerve thresholds, to cause urgency, frequency and even urge incontinence. Several experimental and clinical studies have reported that the NGF is involved in bladder dysfunction, abnormal afferent signaling and bladder sensation. The evidences about relationship between NGF and OAB, and the role of NGF in the development of OAB are reviewed and discussed here.
Keywords: Nerve growth factor; Overactive bladder
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Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
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