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Int Neurourol J > Volume 17(3); 2013 > Article
Han, Choo, Lee, Seo, Kim, Kim, and Lee: Effectiveness of Retropubic Tension-Free Vaginal Tape and Transobturator Inside-Out Tape Procedures in Women With Overactive Bladder and Stress Urinary Incontinence

ABSTRACT

Purpose

We compared the effectiveness of the retropubic tension-free vaginal tape (TVT) and the transobturator inside-out tape (TVT-O) in treating symptoms of overactive bladder (OAB) in women with stress urinary incontinence (SUI).

Methods

Women with urodynamic SUI and OAB (mean urgency episodes ≥1 and frequency ≥8/24 hours on a 3-day voiding diary) were assigned to the TVT or TVT-O group. Preoperative measures were based on a urodynamic study, 3-day voiding diary, the Bristol Female Lower Urinary Tract Symptoms questionnaire (BFLUTSSF), and the urgency perception scale (UPS). At 12 postoperative months, the 3-day voiding diary, symptoms questionnaire, patient satisfaction, and standing stress test were assessed. The primary endpoint was change in the number of urgency episodes/24 hours from baseline to 12 months.

Results

In this group of 132 women, 42 received TVT and 90 received TVT-O. The mean urgency episodes/24 hours decreased from 6.3±5.5 to 1.6±3.2 in the TVT group and from 5.1±4.4 to 1.8±3.0 in the TVT-O group. The mean percent change was significantly greater after TVT than after TVT-O (73% vs. 60%, P=0.049). All subscales of BFLUTSSF and UPS were significantly improved using either method, with significantly greater improvement seen in the quality of life (QoL) domain after TVT (P=0.002). There were no significant differences in the cure and satisfaction rates between the two groups.

Conclusions

Intervention with the TVT or the TVT-O significantly improved symptoms of OAB in women with SUI and OAB. Urgency and QoL significantly improved after TVT compared with that after TVT-O.

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    INTRODUCTION

    Since its introduction as a minimally invasive procedure, the midurethral sling (MUS) has become the most widely used treatment for female stress urinary incontinence (SUI). After more than 10 years' follow-up, retropubic tension-free vaginal tape (TVT) has shown to yield long-term cure rates of 84-90% [1,2], and transobturator tape (TOT) procedures have comparable effectiveness to that of TVT [3,4]. Overactive bladder (OAB) symptoms can also be cured during operation for incontinence, although no satisfactory explanation can be provided for this. Approximately 50% of women suffering from SUI have coexisting symptoms of OAB [5,6]. In addition, those who undergo surgery for SUI have high expectations of a good outcome; in particular, patients expect that their OAB symptoms should be resolved as well [7]. If these symptoms are not resolved, patients may consider the surgery to be ineffective. Moreover, the coexistence of OAB and SUI reduces patient quality of life (QoL) more than that experienced by patients with SUI alone [8,9]. For these reasons, it is important to assess the effect of surgery for SUI on the symptoms of OAB.
    The cure rate of preoperative urgency or urgency urinary incontinence (UUI) symptoms following MUS varies from 23% to 75% [10-14]. Most studies on changes in OAB after MUS focused on women who underwent surgery primarily for SUI. In these studies, symptoms of OAB were not the primary outcome measures, and standardized, validated tools for assessing OAB were not used. Therefore, the objective of the present study was to compare the effectiveness of the TVT and transobturator vaginal tape inside-out (TVT-O) on OAB symptoms in women with both SUI and OAB.

    MATERIALS AND METHODS

    Design

    This was a prospective, multicenter, comparative study performed at 10 institutions. The subjects received detailed information about the study procedure and provided written consent to participate.

    Population

    Women at 18 years of age and older with both urodynamic SUI and OAB were eligible for inclusion in the study. OAB was defined as urgency (≥3 points on a five-point urinary sensation scale [USS]; 1, no urgency to 5, urgency incontinence) [15] more than one time per day and more than eight times per day on a 3-day voiding diary. Patients were excluded if they had a neurological disease or pelvic organ prolapse stage ≥2, or if they were being treated with any behavioral therapy, anticholinergic drug for OAB, or any drug treatment that might affect micturition 14 days prior to enrollment and throughout the trial.

    Procedure

    Consenting patients were assigned to the TVT or TVT-O for OAB symptoms based on the surgeon's preference at a given institution. The TVT and TVT-O procedures were performed by experienced surgeons using standard techniques provided by Ulmsten et al. [16] and de Leval [17]. A combination of light sedation and local anesthesia was normally used, but general or spinal anesthesia was also used according to each center's protocols.

    Assessment

    The preoperative protocol included clinical, neurological, and urogynecological examinations, a 3-day voiding diary, including an urgency scale, and a urodynamic study. The urodynamic study was performed in accordance with International Continence Society standards [18]. Scored forms of the Bristol Female Lower Urinary Tract Symptoms questionnaire (BFLUTSSF) [19] and Urgency Perception Scale (UPS) [20] were analyzed. At 12 months after the operations, outcome measures included a 3-day voiding diary recording the urgency scale, symptom questionnaires, standing stress test, and patient's satisfaction assessment by a data collector. The objective cure of SUI was defined as a negative standing stress test, while the subjective cure was based on responses on the Sandvik questionnaire [21]. Cure of UUI and urgency were defined as no UUI and no urgency based on the voiding diary. Twelve months after the surgery, patients were asked to describe their overall satisfaction using answers such as very satisfied, satisfied, or not satisfied. All patients, except those self-described as not satisfied, were considered satisfied.
    The primary endpoint was the change in number of urgency episodes per 24 hour from the baseline to the 12-month postoperative visit. The secondary endpoints were the objective cure of SUI, patient satisfaction with treatment, the changes in symptom questionnaire answers (BFLUTSSF and UPS), and voiding function changes from baseline to the 12-month postoperative visit.

    Statistical Analysis

    SPSS ver. 12.0 (SPSS Inc., Chicago, IL, USA) was used for the data management and analysis. The Wilcoxon, Fisher exact, and chi-square tests were used to test homogeneity between the TVT and TVT-O groups. Within-group comparisons were analyzed using the Wilcoxon test or a paired t-test as appropriate. A P-value <0.05 indicated significance.

    RESULTS

    We assessed 158 consecutive patients in this study. Among these, 132 patients (42 in the TVT group and 90 in the TVT-O group) were included in the efficacy analysis (Fig. 1). The demographic and preoperative characteristics were similar between groups (Table 1).
    After the operation, the mean number of urgency episodes per 24 hours decreased from 6.3±5.5 to 1.6±3.2 in the TVT group and from 5.1±4.4 to 1.8±3.0 in the TVT-O group. The mean changes in urgency were greater in the TVT group than in the TVT-O group (-4.7/24 hours vs. -3.3/24 hours), but the difference was not significant (P=0.216). When mean percent changes in voiding diary parameters were compared, only the mean percent change in the number of urgency episodes was found to differ between groups, and was significantly greater in the TVT than in the TVT-O group (74% vs. 60%, P=0.049) at 12 months (Fig. 2). The overall objective cure rates for SUI were 95.2% (40/42) in the TVT and 92.2% (83/90) in the TVT-O group (P=0.718). Subjective cure rates for SUI were 85% (34/40) in the TVT and 79.6% (70/88) in the TVT-O group (P=0.340). All subscales of BFLUTSSF (voiding, filling, incontinence, sexual function, and QoL) were improved in both groups, but the improvement in the QoL domain was significantly higher in the TVT group (P=0.002) (Fig. 3).
    Table 2 summarizes changes in the voiding diary and uroflowmetry parameters and between the TVT and TVT-O groups. In both groups, urination frequency and nocturia as well as urgency and UUI were significantly improved after surgery. The severity of the urgency and the maximum voided volume were significantly decreased after surgery, while the changes in the TVT group were significantly greater than those in the TVT-O group (P=0.049 and P=0.002, respectively).
    The cure rates for urgency (53% for TVT [20/38] vs. 51% for TVT-O [43/84], P=0.809) and those for UUI (55% for TVT [21/38] vs. 52% for TVT-O [44/84], P=0.836) did not differ significantly between the two groups. After surgery, UPS was also significantly improved, and the improvement rates did not differ between the groups. The rates of patient satisfaction were 95.2% in the TVT group (40/42) and 96.7% (87/90) in the TVT-O group (P=0.653).

    DISCUSSION

    In this study, we prospectively compared the effectiveness of TVT and TVT-O in treating OAB symptoms using validated objective and subjective measures in women with both SUI and OAB. Both TVT and TVT-O resulted in significant improvement in OAB symptoms. However, the number of urgency episodes, urgency grade, and maximum voided volume greatly improved with TVT than with TVT-O. Furthermore, TVT was associated with higher improvement postoperative QoL compared with TVT-O. We assume that the greater effectiveness of TVT as compared to TVT-O in treating OAB produced a correspondingly greater improvement in QoL.
    To date, the relative effectiveness of the route of MUS procedures for OAB in SUI patients remains controversial. Therefore, the cure rate of OAB symptoms varies wide depending on the different parameters, unlike the parameters considered for SUI symptoms. Botros et al. [10] found that for UUI, the TOT produces a higher success rate than TVT or the suprapubic arc sling procedure. In addition, 14-16% of patients with preoperative UUI who underwent TVT or SPARC experienced worsening of their symptoms compared to only 6% of those treated by TOT. Porena et al. [22] reported that symptoms of storage, including daytime frequency, nocturia, and urgency, significantly improved or disappeared following treatment with TOT; however, these symptoms persisted in 24% of patients compared to 44% in patients treated with TVT. However, in another comparative study of TVT and TVT-O for lower urinary tract symptoms, changes in voiding and storage symptom scores on the American Urological Association Symptom Index before and after the procedure did not differ significantly [23]. In a recent meta-analysis on the effectiveness of MUS for mixed urinary incontinence, no significant difference in UUI cure was observed between the tapes used by the retropubic or transobturator routes [24].
    It is unclear why the effects on OAB symptoms, including UUI, differ when retropubic and transobturator routes of midurethral tape replacement are used. One explanation may be because of the differences in the angle between the two limbs of the mesh used in TVT and TVT-O. SUI can induce and/or increase detrusor instability when intra-abdominal pressure is increased. Urine then enters the proximal urethra, increasing bladder activity and stimulating the urethral afferents [25]. An ultrasonographic study showed that, at rest, the tape is more open in the TOT and TVT-O treatments than in the TVT, and that a larger angle at rest is significantly associated with recurrent SUI [26]. At maximum retention, the angle closes through the traction of the two arms, with the lavatory plate raising the anterior vaginal wall. As intra-abdominal pressure increases, these tapes work as a dynamic closing mechanism that affects the urethra. Therefore, we hypothesize that the greater angular closure provided by the TVT may more effectively prevent urine from entering the upper posterior urethra, thereby improving reflex urgency to a greater degree than TVT-O. To support our hypothesis, however, long-term data are needed to demonstrate a correlation between postoperative UUI and OAB symptoms and tape angulation.
    The difference in the outcome of these procedures might alternatively depend on tape position. An appropriately performed TVT involves minimal dissection and placement of the tape tension-free around the midurethra. Rezapour and Ulmsten [14] assumed that because of this, the proximal part of the densely innervated urethra and bladder neck would be less compromised to the benefit of UUI. In the case of the TOT, however, a longer suburethral incision and a larger paraurethral dissection are needed compared to that needed in the TVT because the index finger has to enter the paraurethral dissection. A study conducted to verify whether the TOT tape did not move from the midurethral space, resulting in subsequent voiding difficulty [27] found no difference in tape position, even though the TOT was closer to the bladder neck than the TVT. The authors noted that their finding was not statistically significant, and that the study lacked the statistical power to detect a difference. Larger-scale studies are needed to establish the effect of tape position on changes in OAB symptoms via surgery.
    The mixed symptoms observed may be due to a more severe form of incontinence caused predominantly by stress [28], explaining why mixed symptoms are resolved after successful MUS. When patients report a sudden loss of urine associated with urgency, this condition may represent SUI combined with waiting too long to void rather than true urgency or UUI. In addition, patients may adopt behaviors of frequency as a strategy to control SUI. Such patients can be cured after anti-incontinence surgery compared with those who have true severe UUI. Consistent with this theory, we found that frequency as well as urgency or UUI decreased significantly after surgery. However, this hypothesis does not easily explain why the TVT procedure would more readily resolve urgency symptoms. Despite the use of reliable tools to assess OAB, including a validated questionnaire and UPS, we cannot exclude the possibility of data confounding by "pseudo-urge symptoms" [11].
    Additional limitations of this study include its small population size, the relatively short follow-up period, and the fact that we allowed the surgeon to decide which procedure to perform by their respective preference for OAB symptoms instead of randomizing the patients. Thus, more surgeons preferred TVT-O over TVT that may have introduced unknown variability into outcome measures. Although few meta-analyses have analyzed the effectiveness of MUS in mixed urinary incontinence, to date, the cure rate of OAB symptoms varies widely according to MUS procedures, and most patients have high expectations of being cured of their OAB symptoms. Therefore, patients were assigned to either the TVT or TVT-O group based on surgeon experience of treating OAB symptoms in patients with SUI, instead of randomizing the patients. In this study, however, the two groups were apparently well matched in baseline clinical characteristics.
    In conclusion, the surgical insertion of TVT and TVT-O significantly improved the OAB symptoms in women with both SUI and OAB. In particular, urgency significantly decreased and QoL significantly improved following TVT compared with TVT-O. Based on these favorable outcomes, TVT may be reasonably proposed as a treatment option in counseling patients who have both SUI and OAB.

    NOTES

    CONFLICT OF INTEREST
    No potential conflicts of interest relevant to this article was reported.

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    Fig. 1
    Participation flowchart. TVT, tension-free vaginal tape; TVT-O, transobturator inside-out tape.
    inj-17-145-g001.tif
    Fig. 2
    Mean percent changes in voiding diary parameters from baseline to 12 months. TVT, tension-free vaginal tape; TVT-O, transobturator inside-out tape; USS, urinary sensation scale; UUI, urgency urinary incontinence.
    inj-17-145-g002.tif
    Fig. 3
    Mean percent change in Bristol Female Lower Urinary Tract Symptoms questionnaire from baseline to 12 months. F, filling; V, voiding; I, incontinence; Sex, sex function; QoL, quality of life; NS, not significant; TVT, tension-free vaginal tape; TVT-O, transobturator inside-out tape.
    inj-17-145-g003.tif
    Table 1
    Baseline characteristics of the intention-to-treat group (n=132)
    Characteristic TVT (n = 42) TVT-O (n = 90) P-value
    Age (yr) 52.5 ± 8.8 (35.0–72.0) 52.3 ± 10.0 (35.0–80.0) 0.710a)
    BMI (kg/m2) 24.6 ± 2.9 (17.0–34.4) 24.4 ± 2.6 (17.4–34.6) 0.744a)
    Parity 2.3 ± 1.0 (0–5) 2.6 ± 1.1 (0–5) 0.380a)
    Hormonal status
     Menopausal 20 (47.6) 42 (47.2) 0.924b)
     On ERT 3 (15) 6 (16) 0.628b)
    Voiding diary
     Frequency/24 hr 10.8 ± 1.8 (8.0–14.7) 11.4 ± 3.0 (8.0–24.7) 1.000a)
     Nocturia/24 hr 2.0 ± 1.2 (0–4.0) 1.9 ± 1.5 (0–7.7) 0.614a)
     Urgency/24 hr 6.3 ± 5.5 (1–23.3) 5.1 ± 4.4 (1–23.0) 0.388a)
     UUI 30 (71.4) 56 (62.2) 0.301b)
     Severity of urgency/voiding 1.7 ± 1.4 (0.1–4.3) 1.3 ± 1.3 (0.1–4.9) 0.145a)
     Maximal voided volume 316.4 ± 125.2 (150.0–800.0) 296.9 ± 84.8 (140.0–600.0) 0.745a)
    Urodynamic parameters
     Peak urinary flow (mL/sec) 24.1 ± 10.1 (9.5–52.3) 24.3 ± 13.3 (6.7–52.9) 0.841a)
     Voided volume (mL) 230.9 ± 84.0 (126.0–398.1) 242.7 ± 133.1 (122.0–675) 0.986a)
     Post-voided residual (mL) 10.5 ± 9.4 (0–43.0) 19.86 ± 29.7 (0–171.0) 0.839a)
     ALPP (cmH2O) 93 ± 36 (36–181) 89 ± 93 (21–209) 0.833a)
     DO 6/26 (23) 15/82 (18) 0.380c)

    Values are presented as mean±standard deviation (range) or number (%).

    TVT, tension-free vaginal tape; TVT-O, transobturator inside-out tape; BMI, body mass index; ERT, estrogen replacement therapy; UUI, urinary urgency incontinence; ALPP, abdominal leak point pressure; DO, detrusor overactivity.

    a)Wilcoxon 2-sample test. b)Fisher exact test. c)Chi-square test.

    Table 2
    Changes in voiding diary and uroflowmetry parameters following TVT and TVT-O
    Variable TVT TVT-O P-valuea)
    Preop Postop Preop Postop
    Urgency/24 hr 6.3 ± 5.5 1.6 ± 3.2b) 5.1 ± 4.4 1.8 ± 3.0b) 0.216
    Voiding diary
     UUI/24 hr 3.2 ± 2.7 0.6 ± 1.0b) 2.7 ± 2.4 1.0 ± 1.6b) 0.096
     Micturition/24 hr 10.8 ± 1.8 7.9 ± 2.4b) 11.4 ± 3.0 7.7 ± 2.9b) 0.407
     Nocturia 2.0 ± 1.2 0.9 ± 1.0b) 1.9 ± 1.5 1.0 ± 1.0b) 1.000
     Urgency severity 1.7 ± 1.4 1.0 ± 1.3b) 1.3 ± 1.3 0.9 ± 1.3b) 0.049
     Maximal voided volume (mL) 316.4 ± 125.2 382.4 ± 152.2b) 296.9 ± 84.8 311.2 ± 88.3 0.041
    Uroflowmetry
     Voided volume (mL) 230.9 ± 84.0 238.7 ± 145.0 242.7 ± 133.1 274.1 ± 100.1b) 0.193
     Qmax (mL/sec) 24.1 ± 18.7 18.7 ± 8.2b) 24.4 ± 10.3 22.9 ± 9.3 0.077
     PVR (mL) 10.5 ± 9.4 24.5 ± 37.3 19.9 ± 29.7 21.2 ± 21.1 0.673

    Values are presented as mean±standard deviation (range).

    TVT, tension-free vaginal tape; TVT-O, transobturator inside-out tape; UUI, urinary urgency incontinence; Qmax, maximum flow rate; PVR, post-void residual.

    a)Comparison between TVT and TVT-O, Wilcoxon 2-sample test. b)P<0.05; comparison between preoperation and postoperation, Wilcoxon 2-sample test.



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